Healthy Science News
- Scientists discover chemical probes for previously 'undruggable' cancer targetHormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously difficult to block with drugs -- but that may soon change. Scientists have identified a crucial binding site […]
- Alzheimer's disease may damage the brain in two phasesAlzheimer's disease may damage the brain in two distinct phases, based on new research using sophisticated brain mapping tools. According to researchers who discovered this new view, the first, early phase happens slowly and silently -- before people experience memory problems -- harming just a few vulnerable cell types. In contrast, the second, late phase […]
- Immune signatures may predict adverse events from immunotherapyDistinct immune 'signatures' in patients who develop adverse events while taking immunotherapy for cancer may help oncologists identify patients at risk and treat them early to prevent serious side effects, suggests a new study.
- Survey finds 25% of adults suspect they have undiagnosed ADHDAttention deficit/hyperactivity disorder -- also known as ADHD -- is typically thought of as a childhood condition. But more adults are realizing that their struggles with attention, focus and restlessness could in fact be undiagnosed ADHD, thanks in large part to trending social media videos racking up millions of views. A new national survey of […]
- Protein involved in balancing DNA replication and restarting foundA protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified.
- Six proteins implicated in early-onset preeclampsiaPreeclampsia is a life-threatening pregnancy complication marked by persistent high blood pressure that is even more serious when it occurs early in the first trimester. The exact cause of early-onset preeclampsia is unknown, and it is difficult to predict, prevent and diagnose. Now researchers report on six proteins that could be used as targets to […]
- Study finds use of naloxone by Good Samaritans is up, but not nearly enoughUse of a lifesaving drug to reverse opioid drug overdoses is growing, but not fast enough.
- Smaller vial size for Alzheimer's drug could save Medicare hundreds of millions per yearMedicare could save up to 74% of the money lost from discarded Alzheimer's drug lecanemab by the simple introduction of a new vial size that would reduce the amount of unused medication that is thrown away. As it is, nearly 6% of the medication is discarded, costing Medicare $1,600 per patient per year.
- Targeting 'undruggable' diseases: New levels of detail in targeted protein degradationTargeted protein degradation has opened up a new field of drug discovery with potential to treat previously 'undruggable' diseases. The work means new drugs can be much more accurately targeted at the molecular level, creating and hitting a metaphorical 'bull's eye.'
- Researchers identify signs tied to more severe cases of RSVClinician-scientists analyzed samples from patients' airways and blood, finding distinct changes in children with severe cases of RSV, including an increase in the number of natural killer (NK) cells in their airways. The descriptive study, which focuses on understanding the underpinnings of severe disease, may help to lay groundwork for identifying new targets for future […]