Researchers have identified a very early marker of cardiac damage in patients undergoing therapy with anthracyclines, a family of drugs commonly used to treat cancer. This finding will enable the early diagnosis of the cardiotoxicity associated with this group of widely used chemotherapy drugs.
The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein. The scientists are now seeking to appropriate this 'suicide' mechanism for therapeutic purposes.
Researchers have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.
From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn't clear. Using new technology to reveal the 3D organization of DNA in maturing male reproductive cells, scientists revealed a crucial period in development that helps explain how […]
Scientists discovered a previously unknown trigger that turns run-of-the-mill strep infections into the flesh-eating disease childbed fever, which strikes postpartum moms and newborns, often leaving victims without limbs. Using an unprecedented approach, they looked at the interplay between the genome, transcriptome and virulence. This generated a massive data set, lending itself to artificial intelligence analysis. […]
Directly activating a gene important to exciting our excitatory neurons and associated with major depression may help turn around classic symptoms like social isolation and loss of interest, at least for males, scientists report.
Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression. While mutations in cancer cells significantly affect drug sensitivity, it is increasingly recognized that ecological interactions between cells can also play a role.
Researchers have identified multiple genetic variants associated with how the body regulates and distributes body-fat tissue. The new findings broaden the understanding of how genes can predispose certain individuals to obesity.
A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.
A high-protein, low-calorie diet helps older adults with obesity lose more weight, maintain more muscle mass, improve bone quality and lose "bad" fat, according to results from a new randomized controlled trial led by Wake Forest University researcher Kristen Beavers.
How bariatric surgery helps people with obesity and diabetes is related to changes in the way the gut senses food and nutrients after the operation, researchers report February 5 in the journal Cell Reports.
Gender-sensitized lifestyle programs delivered in professional football clubs have shown promise in increasing physical activity in Europe and could play an important public health role in engaging underserved men, according to a study published February 5 in the open-access journal PLOS Medicine by Sally Wyke of the University of Glasgow, and colleagues.
It has been speculated earlier that a healthy diet can raise the mood and reduce symptoms of mild depression. A new study proves the cause and effect of healthy diet and improved symptoms of depression.
Experts know that in adults younger than 65, having high cholesterol levels in your blood can raise your risk for heart attacks and strokes. However, in adults 80 years old and older, researchers have not--until now--thoroughly studied high cholesterol's impact on heart disease, your ability to function well, or your risk for death.
Happy Friday! I’m here to tell you that if you aren’t following the Subsys opioid trial you are missing out—salacious and horrifying details galore are emerging, including stories about executives giving doctors lap dances. (Clickbait-y as it may seem, it does paint a damning picture of the roots of this epidemic.) More on that later, […]